Throughout the season it is important to ensure that the players in your fantasy team are in good form and injury-free. We will try to keep this page up to date with the latest WSL Availability News including injuries, absences and expected return dates for each unavailable player. We can’t give guarantee the accuracy or completeness of this page, so always do your own research before selecting a player for your squad.
| Player Name | Club | Status | Reason | Expected Return |
| Amanda Ilestedt | Arsenal | Out | Maternity Leave | Out for the rest of the season |
| Cloé Lacasse | Arsenal | Out | Suspension | Missing GW22 |
| Kaylan Marckese | Arsenal | Out | ACL | Out for the rest of the season |
| Lia Wälti | Arsenal | Out | MCL | Out for the rest of the season |
| Lina Hurtig | Arsenal | Out | Back | Out for the rest of the season |
| Lotte Wubben Moy | Arsenal | Out | Confirmed missing GW22 | |
| Daphne van Domselaar | Aston Villa | Out | Hip | Out for the rest of the season |
| Lucy Stainforth | Aston Villa | Out | Ankle | Out for the rest of the season |
| Chloe Mustaki | Bristol City | Out | Hip | Out for the rest of the season |
| Jess Simpson | Bristol City | Out | ACL | Out for the rest of the season |
| Satara Murray | Bristol City | Out | Knee | Unknown |
| Aniek Nouwen | Chelsea | Out | ACL | Out for the rest of the season |
| Ann Katrin Berger | Chelsea | Out | Transferred to Gotham | |
| Jorja Fox | Chelsea | Out | ACL | Out for the rest of the season |
| Mayra Ramirez | Chelsea | Questionable | Hamstring | |
| Mia Fishel | Chelsea | Out | ACL | Out for the rest of the season |
| Nicky Evrard | Chelsea | Out | Hamstring | Out for the rest of the season |
| Sam Kerr | Chelsea | Out | ACL | Out for the rest of the season |
| Rikke Madsen | Everton | Out | Confirmed missing GW22 | |
| Emily Ramsey | Everton | Out | Ankle | Out for the rest of the reason |
| Lucy Hope | Everton | Out | Confirmed missing GW22 | |
| Karoline Olesen | Everton | Questionable | ||
| Toni Duggan | Everton | Out | Confirmed missing GW22 | |
| Hannah Cain | Leicester City | Out | ACL | Out for the rest of the season |
| Niamh Fahey | Liverpool | Out | Calf | Expected back in training after GW20 |
| Rachel Laws | Liverpool | Out | Finger | Out for the rest of the season |
| Shanice van de Sanden | Liverpool | Out | Ankle | Out for the rest of the season |
| Sofie Lundgaard | Liverpool | Out | Knee | Out for the rest of the season |
| Bunny Shaw | Manchester City | Out | Foot | Out for the rest of the season |
| Jill Roord | Manchester City | Out | ACL | Out for the rest of the season |
| Ellie Roebuck | Manchester City | Out | Occipital Infarct | Out for the rest of the season |
| Sandy MacIver | Manchester City | Out | ACL | Out for the rest of the season |
| Emma Watson | Manchester United | Out | ACL | Out for the rest of the season |
| Gabrielle George | Manchester United | Out | ACL | Out for the rest of the season |
| Abbey-Leigh Stringer | West Ham United | Out | Ankle | Out for the rest of the season |
| Dagný Brynjarsdóttir | West Ham United | Out | Maternity Leave | Out for the rest of the season |
| Katrina Gorry | West Ham United | Out | Ankle | Out for the rest of the season |